Research grant: UEFISCDI PN-II-RU-TE-2011-3-0025
Project coordinator: Lucian FODOR MD, PhD
Institution: EMERGENCY DISTRICT HOSPITAL. FIRST SURGICAL CLINIC. PLASTIC AND RECONSTRUCTIVE SURGERY UNIT

Project enrollment period: 28.10.2011-27.10.2014

 

 
A NEW METHOD FOR BURNS TREATMENT - IMPROVING THE WOUND HEALING USING TOPICAL ADMINISTRATION OF ANABOLIC HORMONES AND BIOMATERIALS
 
 
O noua metoda de tratament a arsurilor - Imbunatatirea vindecarii plagilor prin
aplicarea locala de hormoni anabolizanti si biomateriale
 

 

 
Abstract. Burns represent a pathology with major social impact and with severe repercussions upon the quality of life of the patients. This is mainly due to the complications like scar contractures which lead to functional impairment of the affected areas. The main objective of the study is to speed the wound healing of the burn areas with minimal scarring. Therefore we will investigate the influence of oxandrolone and of the recombinant growth hormone (rGH) on burn wound healing in rabbits. This will be a prospective double blind study on animals with symmetric burns on the anterior limbs and on the trunk. The two hormones will be delivered topically using two carrier biomaterials: the hyaluronic acid and collagen type I hydrogels on four groups.. On the opposite burn wound we will apply only the control represented by the biomaterial. The healing of the burn wounds and scars will be monitored clinically. The degree of contraction, the physical properties of the scars will be quantified using a goniometer and a tensiometer. Through microscopy, immunohistochemistry and biochemistry studies we will investigate the collagen type, the presence of myofibroblasts and of the neovascularization. The statistical analysis of the data and the interpretation of the results will be done side by side in each group and also between groups. In parallel we will aim the specialization of the early stage researchers, the dissemination of the results through articles publication, congress presentation.
 
Team Members
 
1.      Lucian Fodor
2.      Codrin Dobreanu
3.      Raluca Sobec
4.      Cristian Magdas
5.      Marius Fodor

6.      Sanda Avram

 

Results

Scientific activity

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